Breathing in negative ions is generally considered safe for humans, as these particles are already present in our environment from sources such as sunlight, lighting, and waterfalls. However, the ozone production of ionic air purifiers can be a potential health hazard. Inhaling ozone, even in small amounts, can cause throat irritation, coughing, chest pain, and difficulty breathing. It can also increase the risk of respiratory infections. Air ionizers are designed to help provide cleaner air and they do this by releasing ionized particles.
Generally speaking, these ionizers are not powerful enough to be harmful to humans. For example, I have a Therapure TPP300D with UV+ ionizer that runs for 8 hours a day in my living room. Despite the conflicting data surrounding the safety of ionizers, I usually keep my option turned off.